Utilization of Anting-Anting (Acalypha indica) Leaves as Antibacterial

Workshop and International Seminar on Science of Complex Natural Systems

Batubara, Irmanida^1,2 ; Wahyuni, Wulan Tri^1,2 ; Firdaus, Imam^1,2

Department of Chemistry, Faculty of Mathematics and Natural Science, Bogor Agricultural University, Darmaga Campus, Bogor, Indonesia^1

Biopharmaca Research Center, Bogor Agricultural University, Jl Taman Kencana No 3, Bogor

16128, Indonesia^2

关键词: Acalypha indica;    Active fraction;    Degradation activity;    IC50 value;    Microdilution;    Minimum bactericidal concentrations;    Minimum inhibitory concentration;    Streptococcus mutans;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/31/1/012038/pdf
DOI  :  10.1088/1755-1315/31/1/012038

来源: IOP

【 摘 要 】

Anting-anting (Acalypha indica) plants is a species of plant having catkin type of inflorescence. This research aims to utilize anting-anting as antibacterial toward Streptococcus mutans and degradation of biofilm on teeth. Anting-anting leaves were extracted by maceration technique using methanol, chloroform, and n-hexane. Antibacterial and biofilm degradation assays were performed using microdilution technique with 96 well. n-Hexane extracts of anting-anting leaves gave the best antibacterial potency with minimum inhibitory concentration and minimum bactericidal concentration value of 500 μg/mL and exhibited good biofilm degradation activity. Fraction of F3 obtained from fractionation of n-hexane's extract with column chromatography was a potential for degradation of biofilm with IC50value of 56.82 μg/mL. Alkaloid was suggested as antibacterial and degradation of biofilm in the active fraction.