Pulmonary thromboembolism in AIDS patient with chronic venous insufficiency, pulmonary tuberculosis and breast cancer: a case report and pathophysiology review

Revista do Instituto de Medicina Tropical de São Paulo

Juan José Cortez-escalante²  Cleudson Castro²  Gustavo Adolfo Sierra Romero²  Luiza Matos²  Muhammad Wasif Saif¹ 

[1] ,Universidade de Brasília Núcleo de Medicina Tropical Brasília DF ,Brasil

关键词: Thrombosis;    Pulmonary thromboembolism;    HIV infection;    AIDS;    Tuberculosis;   

DOI  :  10.1590/S0036-46652006000200010

来源: SciELO

【 摘 要 】

Recent literature reports thrombotic episodes occurring in patients with HIV infection associated with other abnormalities including neoplasms and infections predisposing to a hypercoagulable state. We report a 47-year-old woman who developed pulmonary thromboembolism in association with HIV infection, pulmonary tuberculosis and breast cancer. She was treated with rifampin, isoniazid, pyrazinamide; heparin, phenprocoumon, zidovudine, lamivudine and efavirenz. Acid fast bacilli were visualized in a sputum smear and three months after, Mycobacterium tuberculosis was isolated from lymph node biopsy during a episode of immune reconstitution. The isolated mycobacteria showed sensitivity to all first-line drugs. HIV infection, breast cancer and pulmonary tuberculosis have several mechanisms that induce hypercoagulable state and can lead to thromboembolic complications. Pulmonary thromboembolism in this patient was a diagnostic challenge because of all the other severe diseases that she experienced at the same time.

【 授权许可】

CC BY-NC   
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