Antifungal susceptibilities of clinical and environmental isolates of Cryptococcus neoformans in goiânia city, Goiás, Brasil

Revista do Instituto de Medicina Tropical de São Paulo

Lúcia Kioko Hasimoto Souza²  Orionalda De Fátima Lisboa Fernandes²  Cláudia Castelo Branco Artiaga Kobayashi²  Xisto Sena Passos²  Carolina Rodrigues Costa²  Janine Aquino Lemos²  Ary Henrique Souza-júnior¹  Maria Do Rosário Rodrigues Silva² 

[1] ,Universidade Federal de Goiás Instituto de Patologia Tropical e Saúde Pública Laboratório de MicologiaGoiânia Goiás ,Brazil

关键词: Cryptococcus neoformans;    Antifungal agents;    Cerebrospinal fluid;    Environment;   

DOI  :  10.1590/S0036-46652005000500003

来源: SciELO

【 摘 要 】

We evaluated the antifungal activities of amphotericin B, fluconazole, itraconazole and voriconazole in 70 Cryptococcus neoformans strains obtained from cerebrospinal fluid from AIDS patients and 40 C. neoformans strains isolated from the environment. Four clinical isolates were identified as C. neoformans var. gattii. The susceptibility test was done using a broth microdilution method according to NCCLS M27-A2. Range minimal inhibitory concentrations (MICs) for C. neoformans clinical isolates were 0.06-1.0 µg/mL for amphotericin B, 0.125-8 µg/mL for fluconazole, 0.03-0.5 µg/mL for itraconazole and 0.03-0.25 µg/mL for voriconazole. C. neoformans environmental isolates showed range MICs 0.015-0.125 µg/mL, 0.25-2.0 µg/mL, 0.007-0.125 µg/mL and 0.03-0.25 µg/mL for amphotericin B, fluconazole, itraconazole and voriconazole respectively. The MICs results obtained from clinical and environmental isolates showed similar pattern of susceptibility and no resistance has been found in our isolates.

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