In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Sydney Hartz Alves²  Loiva T. Oliveira¹  Jane M. Costa¹  Irina Lubeck¹  Agnes Kiesling Casali¹  Marilene Henning Vainstein¹ 

[1] ,Universidade Federal de Santa Maria Laboratório de Pesquisas Micológicas Departamento Análises Clínicas e ToxicológicasSanta Maria RS ,Brasil

关键词: Cryptococcus neoformans;    Susceptibility;    Antifungal agents;   

DOI  :  10.1590/S0036-46652001000500006

来源: SciELO

【 摘 要 】

The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed.

【 授权许可】

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