Leptospirosis severity may be associated with the intensity of humoral immune response

Revista do Instituto de Medicina Tropical de São Paulo

Regina C.r.m. Abdulkader²  Elizabeth F. Daher¹  Eide D. Camargo¹  Cláudia Spinosa¹  Marcos Vinícius Da Silva¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Hospital das ClínicasSão Paulo SP ,Brasil

关键词: Leptospirosis;    Humoral immune response;    Antibody avidity;   

DOI  :  10.1590/S0036-46652002000200005

来源: SciELO

【 摘 要 】

Leptospirosis severity may be increasing, with pulmonary involvement becoming more frequent. Does this increase result from an intense immune response to leptospire? Notice that renal failure, thrombocytopenia and pulmonary complications are found during the immune phase. Thirty-five hospitalized patients with Weil's disease had 5 blood samples drawn, from the 15th day to the 12th month of symptoms, for ELISA-IgM, -IgG and -IgA specific antibody detection. According their 1st IgG titer, the patients were divided into: group 1 (n = 13) titer > 1:400 (positive) and group 2 (n = 22) titer <=1:400 (negative). Early IgG antibodies in group 1 showed high avidity which may indicate reinfection. Group 1 was older, had worse pulmonary and renal function, and fever for a longer period than group 2. Throughout the study, IgG and IgA titers remained higher in group 1. In conclusion, the severity of Weil's disease may be associated with the intensity of the humoral immune response to leptospire.

【 授权许可】

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