Liver histology in co-infection of hepatitis C virus (HCV) and Hepatitis G virus (HGV)

Revista do Instituto de Medicina Tropical de São Paulo

Edna Strauss²  Luiz Carlos Da Costa Gayotto²  Fabian Fay¹  Oscar Fay¹  Helena Sabino Fernandes¹  Dalton De Alencar Fischer Chamone¹ 

[1] ,FMUSP Divisão de Anatomia Patológica São Paulo SP ,Brasil

关键词: Hepatitis C;    Hepatitis G;    Liver fibrosis;    Inflammatory activity;   

DOI  :  10.1590/S0036-46652002000200003

来源: SciELO

【 摘 要 】

As little is known about liver histology in the co-infection of hepatitis C virus (HCV) and hepatitis G virus (HGV), HGV RNA was investigated in 46 blood donors with hepatitis C, 22 of them with liver biopsy: co-infection HCV / HGV (n = 6) and HCV isolated infection (n = 16). Besides staging and grading of inflammation at portal, peri-portal and lobular areas (Brazilian Consensus), the fibrosis progression index was also calculated. All patients had no symptoms or signs of liver disease and prevalence of HGV / HCV co-infection was 15.2%. Most patients had mild liver disease and fibrosis progression index, calculated only in patients with known duration of infection, was 0.110 for co-infection and 0.130 for isolated HCV infection, characterizing these patients as "slow fibrosers". No statistical differences could be found between the groups, although a lesser degree of inflammation was always present in co-infection. In conclusion co-infection HCV / HGV does not induce a more aggressive liver disease, supporting the hypothesis that HGV is not pathogenic.

【 授权许可】

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