期刊论文详细信息
Revista do Instituto de Medicina Tropical de São Paulo
Mucosal leishmaniasis ("espundia") responsive to low dose of N-methyl glucamine (Glucantime ®) in Rio de Janeiro, Brazil
Manoel Paes De Oliveira-neto1  Marise Mattos1  Claude Pirmez2  Octavio Fernandes2  Sylvio Celso GonÇalves-costa2  Celeste De Freitas Silva De Souza2  Gabriel Grimaldi Junior2 
[1] ,Fundação Oswaldo Cruz Hospital Evandro Chagas Rio de Janeiro RJ ,Brasil
关键词: Mucosal leishmaniasis;    Leishmania (Viannia) braziliensis;    Antimony;    Therapy;   
DOI  :  10.1590/S0036-46652000000600004
来源: SciELO
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【 摘 要 】

Response to treatment with antimonial drugs varies considerably depending on the parasite strain involved, immune status of the patient and clinical form of the disease. Therapeutic regimens with this first line drug have been frequently modified both, in dose and duration of therapy. A regimen of 20 mg/kg/day of pentavalent antimony (Sb5+) during four weeks without an upper limit on the daily dose is currently recommended for mucosal disease ("espundia"). Side-effects with this dose are more marked in elderly patients, more commonly affected by this form of leishmaniasis. According to our experience, leishmaniasis in Rio de Janeiro responds well to antimony and, in cutaneous disease, high cure rates are obtained with 5 mg/kg/day of Sb5+ during 30 to 45-days. In this study a high rate of cure (91.4%) employing this dose was achieved in 36 patients with mild disease in this same geographic region. Side-effects were reduced and no antimony refractoriness was noted with subsequent use of larger dose in patients that failed to respond to initial schedule.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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