Central nervous system virion detection in acute measles: histopathological, ultrastructural and pathogenetic aspects

Revista do Instituto de Medicina Tropical de São Paulo

C.l.p. Lancellotti²  C.e.p. Corbett¹  M.i.s. Duarte¹ 

[1] ,Faculty of Medical Science of Santa Casa of São Paulo Inst. Infect. of Emilio Ribas São Paulo S. P. ,Brazil

关键词: Measles;    Virus;    Central Nervous System;    Pathology;    Ultrastructure;    Pathogenesis;   

DOI  :  10.1590/S0036-46651995000200008

来源: SciELO

【 摘 要 】

Histopathological and ultrastructural studies of 23 patients who died with clinical diagnosis of measles were carried out. In 12 cases viral nucleocapsids were searched by electron microscopy and detected in 100% of the cases in the lungs and in 50% of the cases in the central nervous system. They were mostly intranuclear. Histopathological changes associated to neurological alterations and the detection of virion are discussed in relation to acute and delayed clinical manifestations.

【 授权许可】

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