Is rhabdomyolysis an additional factor in the pathogenesis of acute renal failure in leptospirosis?

Revista do Instituto de Medicina Tropical de São Paulo

Reinaldo Martinelli¹  Marcos A. Luna¹  Heonir Rocha¹ 

[1] ,Universidade Federal da Bahia Faculdade de Medicina Departamento de MedicinaSalvador Bahia

关键词: Renal failure;    Rhabdomyolysis;    Leptospirosis;   

DOI  :  10.1590/S0036-46651994000200003

来源: SciELO

【 摘 要 】

Leptospirosis is an important cause of acute renal failure in our environment. Although several mechanisms are implicated, the role of rhabdomyolysis in the pathogenesis of acute renal failure in leptospirosis has not been analysed. Sixteen patients with the diagnosis of leptospiroses consecutively admitted to the hospital were prospectively studied. The disease was characterized by sudden onset in all patients and, at admission, jaundice, conjunctival suffusion and myalgias. Mild to moderate proteinuria with unremarkable urinary sediment was recorded in 37.5% of the patients and abnormal levels of urea creatinine were found in 87.5% and 74.0%, respectively. Increased levels of aminotranspherase were documented in all 12 and CPK in all 10 patients studied. Serum myoglobin levels greater than 120µg/l recorded in 56.2%. A correlation between myoglobin and renal failure or severity of disease, however, could not be established.

【 授权许可】

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