Immunomodulatory effect of cimetidine on the proliferative responses of splenocytes from T. cruzi-infected rats

Revista do Instituto de Medicina Tropical de São Paulo

M.n. Sato¹  E.h. Yamashiro-kanashiro¹  M.m. Tanji¹  R. Kaneno¹  R.y. Iqueoka¹  A.j.s. Duarte¹ 

[1] ,Universidade de São Paulo Faculdade de Medicina Disciplina de Alergia e ImunopatologiaSão Paulo SP

关键词: Trypanosoma cruzi;    Rat;    Inbred strain;    Cimetidine;    Immunoregulation;   

DOI  :  10.1590/S0036-46651991000300004

来源: SciELO

【 摘 要 】

The immunomodulatory effect of cimetidine (CIM), a histamine type-2 receptor antagonist, was evaluated in respect to the blastogenic response to Con A of Wistar Furth (WF) rats infected by the Y strain of Trypanosoma cruzi (T. cruzi). Enhancement of blastogenesis of normal splenocytes was observed at a concentration of 10-3M. However, the splenocytes from infected animals responded to concentrations of CIM ranging from 10-8 to 10-3M. The mitogenic response to Con A of cells from infected animals was restored in the presence of CIM. The results show that CIM modulates the "in vitro" proliferative response of cells from T. cruzi-infected rats and suggest an immunoregulatory role of histamine and/or of cells that express H2 receptors in this infection.

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