Measles vaccination: influence of age on its efficacy

Revista do Instituto de Medicina Tropical de São Paulo

Marta Heloísa Lopes²  João Silva De Mendonça¹  Cláudio Sérgio Pannuti²  Paul Albrecht¹  Maria Lúcia Neves Biancalana¹  Orlando César Mantese¹  José Fábio Correa¹  Vicente Amato Neto² 

[1] ,Universidade de São Paulo Faculdade de Medicina Departamento de Doenças Infecciosas e ParasitáriasSão Paulo SP ,Brazil

关键词: Measles vaccine;    Measles;    Children immunization;   

DOI  :  10.1590/S0036-46651989000500005

来源: SciELO

【 摘 要 】

The authors compare the serologic efficacy and the clinical protection afforded by three different measles vaccination schemes in adequately nourished children in São Paulo city, Brazil. Two hundred forty two children were divided into three groups. Group A, comprising 117 children who had received the vaccine before 12 months of age and a second dose at 12 months of age or more. Group B, comprising 46 children who had received only one dose, before 12 months of age. Group C, comprising 79 children who had received only one dose, at 12 months of age or more. The geometric mean titer of antibodies in Group A was 790.1; in Group B, 251.1; and in Group C, 550.3. There was no statistically significant difference between Groups A and C. The exposure to the measles virus was probably similar in all groups, and the children in Groups A and C had similar chances of acquiring the disease after vaccination whereas in Group B the chances were higher when compared to the other two groups. The results obtained in this study favor the use, in developing countries, of a vaccination program against measles that includes an early first dose at eight months of age and revaccination after 12 months of age.

【 授权许可】

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