Immunopathology of human schistosomiasis mansoni: I. Immunomodulatory influences on T cell function

Revista do Instituto de Medicina Tropical de São Paulo

O. Aldrey¹  B. Noya¹  I. Machado¹  O. Noya¹  N. E. Bianco¹  G. E. Perez¹ 

[1] ,Ministry of Health WHO PAHO Clinical Immunology National Center

关键词: Immunoregulation;    T cells;    Human schistosomiasis;   

DOI  :  10.1590/S0036-46651988000600001

来源: SciELO

【 摘 要 】

Cell mediated immune response was studied in patients with recent and chronic Schistosoma mansoni infection. Precultured peripheral mononuclear cells showed significantly higher responses to S. mansoni adult worm antigen (SAWA) when compared to fresh cell preparations. The addition of each patient serum to the precultured cells reactions to SAWA or recall antigens demonstrated a strong inhibitory serum action, which was also noted on allogeneic cells derived from healthy subjects. The CD4 subset was the main responding cell to SAWA being this reactivity highly suppressed by the presence of the monocyte macrophage accessory cells. We stressed the simultaneous inhibitory action of humoral and cellular factors on the specific cell response to S. mansoni.

【 授权许可】

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