Increased multiple sclerosis relapses related to lower prevalence of pain

Arquivos de Neuro-Psiquiatria

José Vinícius Martins Da Silva¹  Beatriz Fátima Alves De Oliveira¹  Osvaldo José Moreira Do Nascimento¹  João Gabriel Dib Farinhas¹  Maria Graziella Cavaliere¹  Henrique De Sá Rodrigues Cal¹  André Palma Da Cunha Matta¹ 

关键词: multiple sclerosis;    pain;    prevalence;    relapses;    gender;    esclerose múltipla;    dor;    prevalência;    surto;    sexo;   

DOI  :  10.1590/0004-282X20150073

来源: SciELO

【 摘 要 】

Objective The study aims to investigate the presence of pain amongst multiple sclerosis (MS) patients. Method One hundred MS patients responded to questionnaires evaluating neuropathic and nociceptive pain, depression and anxiety. Statistical analysis was performed using the Mann–Whitney U, Chi-Square and two-tailed Fisher’s exact tests and multivariate logistic regression. Results Women had a statistically higher prevalence of pain (p = 0.037), and chances of having pain after the age of 50 reduced. Women with pain had a statistically significant lower number of relapses (p = 0.003), restricting analysis to those patients with more than one relapse. After the second relapse, each relapse reduced the chance of having pain by 46%. Presence of pain was independent of Expanded Disability Status Scale (EDSS) anxiety, and depression. Conclusion Our findings suggest a strong inverse association between relapses and pain indicating a possible protective role of focal inflammation in the control of pain.

【 授权许可】

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