Sleep Disorders Reduce Health-Related Quality of Life in Multiple Sclerosis (Nottingham Health Profile Data in Patients with Multiple Sclerosis)

International Journal of Molecular Sciences

Christian Veauthier¹  Gunnar Gaede³  Helena Radbruch³  Klaus-Dieter Wernecke²  Friedemann Paul³ 

[1] Interdisciplinary Center for Sleep Medicine, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany;CRO SOSTANA GmbH and Charité University Medicine Berlin, Wildensteiner Straße 27, 10318 Berlin, Germany; E-Mail:;NeuroCure Clinical Research Center, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany; E-Mails:

关键词: restless legs syndrome;    sleep disorders;    multiple sclerosis;    clinical neurophysiology;    polysomnography;    insomnia;    pain;    depression;    health;    quality of life;   

DOI  :  10.3390/ijms160716514

来源: mdpi

【 摘 要 】

Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17). Subsequently, we classified the patients into four subgroups: insomnia (n = 17), restless-legs syndrome, periodic limb movement disorder and SD due to leg pain (n = 24), obstructive sleep apnea (n = 8) and patients without sleep disorder (n = 17). OSA and insomnia patients showed significantly higher NHP values and decreased HRQoL not only for the sleep subscale but also for the “energy” and “emotional” area of the NHP. In addition, OSA patients also showed increased NHP values in the “physical abilities” area. Interestingly, we did not find a correlation between the objective PSG parameters and the subjective sleep items of the NHP. However, this study demonstrates that sleep disorders can reduce HRQoL in MS patients and should be considered as an important confounder in all studies investigating HRQoL in MS.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.