Supplementation and therapeutic use of vitamin D in patients with multiple sclerosis: Consensus of the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology

Arquivos de Neuro-Psiquiatria

Doralina Guimarães Brum¹  Elizabeth Regina Comini-frota¹  Claúdia Cristina F. Vasconcelos¹  Elza Dias-tosta¹ 

关键词: vitamin D;    multiple sclerosis;    experimental autoimmune encephalitis;    Vitamina D;    esclerose múltipla;    encefalite autoimune experimental;   

DOI  :  10.1590/0004-282X20130252

来源: SciELO

【 摘 要 】

Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there is evidence that genetic and environmental factors interact to cause the disease. Among the main environmental factors studied, those more likely associated with MS include certain viruses, smoking, and hypovitaminosis D. This review aimed to determine whether there is evidence to recommend the use of vitamin D as monotherapy or as adjunct therapy in patients with MS. We searched PUBMED, EMBASE, COCHRANNE, and LILACS databases for studies published until September 9 th , 2013, using the keywords “multiple sclerosis”, “vitamin D”, and “clinical trial”. There is no scientific evidence up to the production of this consensus for the use of vitamin D as monotherapy for MS in clinical practice.

【 授权许可】

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