Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

Arquivos de Neuro-Psiquiatria

João Guilherme Fiorani Borgio²  Leonardo Baldaçara¹  Walter Dos Santos Moraes²  Acioly L. T. Lacerda¹  Maria Beatriz Montaño¹  Andrea Parolin Jackowski¹  Sérgio Tufik²  Luiz Roberto Ramos¹  Rodrigo Affonseca Bressan¹ 

[1] ,Universidade Federal de São Paulo (UNIFESP) Department of Psychobiology São Paulo SP ,Brazil

关键词: geriatric psychiatry;    neuroimage;    mild cognitive impairment;    psiquiatria geriátrica;    neuroimagem;    distúrbio cognitivo leve;   

DOI  :  10.1590/S0004-282X2012001100003

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB) and hippocampal volume (HV) as predictors of conversion from mild cognitive impairment (MCI) to dementia. METHODS: Twenty-eight individuals (9 normal and 19 with MCI) were classified according to their CDR sum of boxes scores into 3 groups. RESULTS: The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION: We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

【 授权许可】

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