What should you know about limbic encephalitis?

Arquivos de Neuro-Psiquiatria

Sara Machado¹  Amélia Nogueira Pinto¹  Sarosh R. Irani² 

[1] ,University of Oxford Department of Clinical Neurosciences ,United Kingdom

关键词: limbic autoimmune encephalitis;    encephalopathy;    intracellular antigens;    membrane surface antigens;    VGKC-complex;    LGI1;    CASPR2;    N-methylaspartate;    paraneoplastic syndrome;    immunotherapy;    encefalite límbica autoimune;    encefalopatia;    antigénios intracelulares;    antigénios da superfície de membrana;    complexo VGKC;    LGI1;    CASPR;    N-metilaspartato;    síndrome paraneoplásica;    imunoterapia;   

DOI  :  10.1590/S0004-282X2012001000012

来源: SciELO

【 摘 要 】

Autoimmune encephalitis is an inflammatory disorder characterized by a subacute impairment of short-term memory, psychiatric features and seizures. It is often associated with a variety of other neurological symptoms, and its differential diagnosis is wide, leading to challenges in its recognition. It used to be regarded as a rare disease, usually paraneoplastic and with poor prognosis. However, with the recent recognition of membrane-surface directed antibodies, it is now known that in a substantial proportion of cases there is no association with any malignancy and there is a good prognosis if treated. Hence, early recognition and prompt initiation of immunotherapies are of great importance.

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