Difficulties in HAM/TSP diagnosis

Arquivos de Neuro-Psiquiatria

Carla Maria Sena Andrade Slater²  Luiz Claudio Pereira Ribeiro¹  Marzia Puccioni-sohler¹ 

[1] ,Universidade Federal do Estado do Rio de Janeiro Hospital Universitário Gaffrée e Guinle Neuroinfection ClinicRio de Janeiro RJ ,Brazil

关键词: HAM/TSP;    Human T-lymphotropic virus 1;    diagnosis;    HAM/TSP;    Vírus linfotrópico de células T humanas tipo 1;    diagnóstico;   

DOI  :  10.1590/S0004-282X2012000900007

来源: SciELO

【 摘 要 】

The World Health Organization recommends the use of Osame's criterion (1990) for the diagnosis of HTLV-I-associated myelopathy (HAM/TSP). In 2006, a group of neurologists developed a Brazilian criterion that can diagnose HAM/TSP from its onset. OBJECTIVE: It was to test the agreement between both criteria. METHODS: The study included evaluation of clinical and laboratory findings of 35 patients. The ELISA, Western blot and/or polymerase chain reaction was used to search for anti-HTLV-I antibodies. The analysis of agreement was based on the calculation of Kappa. RESULTS: Concordance of 100% (Kappa=1) occurred in cases of "defined" HAM/TSP, but not in patients with "probable" diagnosis. CONCLUSION: The Brazilian criteria was as effective as Osame's criteria for the diagnosis of "defined" HAM/TSP. However, both require more specific biological markers in cerebrospinal fluid for the laboratory diagnosis of probable cases.

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