INTERFERON BETA-1A TREATMENT IN HTLV-1-ASSOCIATED MYELOPATHY/TROPICAL SPASTIC PARAPARESIS: A CASE REPORT

Revista do Instituto de Medicina Tropical de São Paulo

Graça Maria De Castro Viana¹  Marcos Antonio Custódio Neto Da Silva¹  Victor Lima Souza¹  Natália Barbosa Da Silva Lopes¹  Diego Luz Felipe Da Silva¹  Maria Do Desterro Soares Brandão Nascimento¹ 

关键词: HAM/TSP;    HTLV-1;    Interferon beta-1a;    Treatment;   

DOI  :  10.1590/S0036-46652014000500013

来源: SciELO

【 摘 要 】

Here a young patient (< 21 years of age) with a history of infective dermatitis is described. The patient was diagnosed with myelopathy associated with HTLV-1/tropical spastic paraparesis and treated with interferon beta-1a. The disease was clinically established as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and laboratory tests confirmed the presence of antibodies to HTLV-1 in the cerebrospinal fluid (CSF). Mumps, cytomegalovirus, Epstein-Barr virus, schistosomiasis, herpes virus 1 and 2, rubella, measles, varicella-zoster toxoplasmosis, hepatitis, HIV, and syphilis were excluded by serology. The patient was diagnosed with neurogenic bladder and presented with nocturia, urinary urgency, paresthesia of the lower left limb, a marked reduction of muscle strength in the lower limbs, and a slight reduction in upper limb strength. During the fourth week of treatment with interferon beta-1a, urinary urgency and paresthesia disappeared and clinical motor skills improved.

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