Language impairment in Huntington's disease

Arquivos de Neuro-Psiquiatria

Mariana Jardim Azambuja¹  Marcia Radanovic¹  Mônica Santoro Haddad¹  Carla Cristina Adda¹  Egberto Reis Barbosa²  Letícia Lessa Mansur¹ 

[1] ,University of São Paulo School of Medicine Department of NeurologySão Paulo SP ,Brazil

关键词: Huntington disease;    language;    movement disorders;    frontal lobe;    caudate nucleus;    doença de Huntington;    linguagem;    transtornos motores;    lobo frontal;    núcleo caudado;   

DOI  :  10.1590/S0004-282X2012000600006

来源: SciELO

【 摘 要 】

Language alterations in Huntington's disease (HD) are reported, but their nature and correlation with other cognitive impairments are still under investigation. This study aimed to characterize the language disturbances in HD and to correlate them to motor and cognitive aspects of the disease. We studied 23 HD patients and 23 controls, matched for age and schooling, using the Boston Diagnostic Aphasia Examination, Boston Naming Test, the Token Test, Animal fluency, Action fluency, FAS-COWA, the Symbol Digit Modalities Test, the Stroop Test and the Hooper Visual Organization Test (HVOT). HD patients performed poorer in verbal fluency (p<0.0001), oral comprehension (p<0.0001), repetition (p<0.0001), oral agility (p<0.0001), reading comprehension (p=0.034) and narrative writing (p<0.0001). There was a moderate correlation between the Expressive Component and Language Competency Indexes and the HVOT (r=0.519, p=0.011 and r=0.450, p=0.031, respectively). Language alterations in HD seem to reflect a derangement in both frontostriatal and frontotemporal regions.

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