Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease

Arquivos de Neuro-Psiquiatria

Quirino Cordeiro²  Ricardo Noguti²  Cássio M.c. Bottino¹  Homero Vallada² 

[1] ,University of São Paulo Medical School Institute of Psychiatry São Paulo SP ,Brazil

关键词: PLA2;    dementia;    gene;    genetics;    LOAD;    PLA2;    demência;    gene;    genética;    Alzheimer de início tardio;   

DOI  :  10.1590/S0004-282X2010000200007

来源: SciELO

【 摘 要 】

Several genes have been related to late-onset Alzheimer's disease (LOAD). Phospholipases A2 (PLA2) influence the processing and secretion of the amyloid precursor protein, which gives rise to the beta-amyloid peptide, the major component of the amyloid plaque in AD. Hence, in the present study, polymorphisms of three genes encoding PLA2 enzymes group (cytosolic PLA2: BanI cPLA2 polymorphism; calcium-independent PLA2: AvrII iPLA2 polymorphism; PAFAH: Val279Phe PAFAH polymorphism) were analysed in a case-control sample using 58 patients with LOAD and 107 matched healthy controls. There was a genotypic association between the BanI cPLA2 polymorphism and LOAD (χ2=6.25, 2df, p=0.04), however there was no allelic association. There were no associations between AvrII iPLA2 and Val279Phe PAFAH polymorphisms and LOAD. These data suggest that the BanI cPLA2 polymorphism may play a role in the susceptibility for LOAD in our Brazilian sample.

【 授权许可】

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