Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies

Arquivos de Neuro-Psiquiatria

Ricardo Mario Arida²  Fulvio Alexandre Scorza¹  Vera Cristina Terra¹  Roberta Monterazzo Cysneiros¹  Esper Abrão Cavalheiro¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Departamento de FisiologiaSão Paulo SP ,Brazil

关键词: exercise;    physical training;    epilepsy;    seizure;    rat;    exercício;    treinamento físico;    epilepsia;    crises;    rato;   

DOI  :  10.1590/S0004-282X2009000600010

来源: SciELO

【 摘 要 】

People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Clinical and animal studies indicate a reduction of seizure frequency as well as decrease susceptibility to subsequently evoked seizures after an exercise program. Analyses from experimental studies of animals with epilepsy submitted to physical training programs were performed. In all studies the physical training was able to reduce the number of spontaneous seizures in rats with epilepsy. Seizure occurrence during exercise was relatively absent in the majority of studies. No death was found in animals with epilepsy during 1680 h of exercise. Based on these results it is plausible encouraging persons with epilepsy to non-pharmacological treatments and preventative measures such as physical exercise.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License