Two Babinski signs in seropositive (HAM) and seronegative tropical spastic paraparesis

Arquivos de Neuro-Psiquiatria

Fidias E. Leon-sarmiento²  Andres Calderon¹  Hernan G. Hernandez¹ 

[1],Fundacion Santa Fe Neurology Section Unit of Movement Disorders and NeuromagnetismoBogota,Colombia

关键词: HAM;    TSP;    Babinski plus sign;    mycotoxins;    neurorehabilitation;    HAM;    TSP;    signo de Babinski plus;    neurorehabilitación;   

DOI  :  10.1590/S0004-282X2008000500016

来源: SciELO

【 摘 要 】

Tropical spastic paraparesis (TSP) may or may not be associated to HTLV-I antibodies and is usually characterized by clinical and pathological spinal cord abnormalities at thoracic levels. We present here five Brazilian patients who had typical chronic idiopatic spastic paraparesis; two of them were HTLV-I seropositive (HAM) and three HTLV-I seronegative (TSP) - associated-myelopathy. Three out of these five patients also displayed clinical supraspinal involvement, indeed, platysma muscle hypotrophy or atrophy (the Babinski plus sign). These findings support the view that clinical involvement in HAM and TSP is wider than the spinal cord abnormalities usually considered. Possible non-infectious co-factors (e.g., mycotoxins) may be involved in disease pathogenesis in a multistep process of viruses, toxins and environment which may account for serological differences found in this group of patients.

【 授权许可】

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