Induction of cytokines in glial cells by trans activator of human T‐cell lymphotropic virus type I

FEBS Letters

Kondo, Noriaki¹  Suzumura, Akio²  Marunouchi, Tohru¹  Sawada, Makoto¹ 

[1] Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-11 Japan;Department of Neurology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-11, Japan

关键词: Glial cell;    HTLV-I;    tax;    Cytokine;    Gene activation;    GM-CSF;    granulocyte-macrophage colony-stimulating factor;    HAM;    HTLV-I associated myelopathy;    HTLV-I;    human lymphotropic virus type I;    IL;    interleukin;    MHC;    major histocompatibility complex;    LPS;    lipopolysaccharide;    PCR;    polymerase chain reaction;    RT;    reverse transcription;    TGF;    transforming growth factor;    TNF;    tumor necrosis factor;    TPA;    12-O-tetradecanoylphorbol-13-acetate;    TSP;    tropical spastic paraparesis;   

DOI  :  10.1016/0014-5793(92)81181-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human T-cell lymphotropic virus type I (HTLV-I), the cause of adult T-cell leukemia, is also associated with the neurological disease, TSP/HAM (tropical spastic paraparesis/HTLV-I associated myelopathy). The HTLV-I genome encodes a protein, Tax, that trans activates viral and cellular gene transcription. To understand the mechanisms for the production of cytokines by HTLV-I in nervous tissue, we examined their expression in glial cells which carried the Tax-expressing vector. We demonstrated that Tax expression enhanced the production by glial cells of interleukin (IL)-1, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor (TGF)β. We suggest that the excessive production of cytokines in nervous tissue may play a role in pathogenesis of TSP/HAM, Glial cells that carry the tax gene may provide a model useful for in vitro study of the mechanism of production of cytokines in the nervous system.

【 授权许可】

Unknown