Use of clozapine in Brazilian patients with Parkinson's disease

Arquivos de Neuro-Psiquiatria

Laura Gomide¹  Arthur Kummer¹  Francisco Cardoso¹  Antonio Lucio Teixeira¹ 

[1] ,University Hospital Service of Neurology Movement Disorders Clinic

关键词: Parkinson's disease;    clozapine;    dyskinesia;    psychosis;    doença de Parkinson;    clozapina;    discinesia;    psicose;   

DOI  :  10.1590/S0004-282X2008000500001

来源: SciELO

【 摘 要 】

Clozapine has been used as an attempt to manage levodopa complications in advanced Parkinson's disease (PD). To investigate the use of clozapine in this context in a Brazilian sample, a retrospective chart review was carried out at the Movement Disorders Clinic from the Federal University of Minas Gerais. This study enrolled 43 PD patients who used or were in use of clozapine. Patients had a mean age of 64 years and a mean UPDRS score of 55. Clozapine was indicated for dyskinesias in 17 patients, for psychosis in 15 and for both reasons in 11. The average maximum dose was 70 mg/day. Twenty six patients used it for a mean of 3.5 years. Twenty nine presented an improvement of their condition, 9 remained clinically stable. Twenty subjects interrupted the use of clozapine, being 9 due to adverse effects. Clozapine may play a role in the management of motor and psychiatric complications in PD, but it is associated with low tolerability.

【 授权许可】

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