sICAM-1 intrathecal synthesis and release during the acute phase in children suffering from Coxsackie A9 and S. pneumoniae meningoencephalitis

Arquivos de Neuro-Psiquiatria

Alberto J. Dorta-contreras¹  Piotr Lewczuk²  Bárbara Padilla-docal¹  Elena Noris-garcía¹  Raisa Bu Coifiu-fanego¹  Consuelo Sánchez-martínez¹  Alexis Rodríguez-rey¹  Marlén González-hernández¹ 

[1],Facultad de Ciencias Médicas Dr. Miguel Enríquez Laboratorio Central de Líquido Cefalorraquídeo Ciudad Habana,Cuba

关键词: cerebrospinal fluid;    sICAM-1;    Coxsackie A9;    Streptococcus pneumoniae;    children;    líquido cefalorraquídeo;    sICAM-1;    Coxsackie A9;    Streptococcus pneumoniae;    niños;   

DOI  :  10.1590/S0004-282X2008000400013

来源: SciELO

【 摘 要 】

The intercellular adhesion molecule is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Serum and cerebrospinal fluid (CSF) soluble intercellular adhesion molecule 1 (sICAM-1) from normal control children as well as from children with Guillain-Barré syndrome (GBS), with Coxsackie A9 virus meningoencephalitis and with Streptococcus pneumoniae meningoencephalitis were studied. sICAM-1 was quantified using an immunoenzimatic assay and albumin using the immunodiffusion technique in both biological fluids. Increased sICAM-1 values in CSF in patients with GBS correspond to an increase of the albumin CSF/serum quotient. In contrast, in inflammatory diseases like S. pneumoniae and Coxsackie A9 virus meningoencephalitis an increased brain-derived fraction was observed. In particular cases these values are 60-65% and 70-75% respectively. The results indicate an additional synthesis of sICAM-1 in subarachnoidal space during central nervous system (CNS) inflammatory process. An important role of sICAM-1 in the transmigration of different cell types into CSF during CNS inflammation in children with S. pneumoniae and Coxsackie A9 meningoencephalitis may be suggested.

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