Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes

Arquivos de Neuro-Psiquiatria

Andrea Maciel De Oliveira Rossoni¹  Libera Maria Dalla Costa²  Denize Bonato Berto²  Sônia Santos Farah²  Marilene Gelain²  Maria Cristina De Cunto Brandileone²  Vitor Hugo Mariano Ramos²  Sergio Monteiro De Almeida² 

[1],Federal University of Paraná Hospital de Clinicas Pediatric ServiceCuritiba PR ,Brazil

关键词: Streptococcus pneumoniae;    pneumococcus;    meningitis;    antimicrobial resistance;    cerebrospinal fluid;    Streptococcus pneumoniae;    pneumococo;    meningite;    resistência antimicrobiana;    líquor;   

DOI  :  10.1590/S0004-282X2008000400014

来源: SciELO

【 摘 要 】

The main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial empirical treatment for meningitis. The sensitiveness and serotypes of all isolated S. pneumoniae of patients with acute bacterial meningitis received by the Paraná State Central Laboratory from April 2001 to august 2002 have been evaluated. One hundred S. pneumoniae have been isolated, of which 15% were resistant to penicillin, 1% to cephalosporin and 0% to vancomycin. The serotypes most found were 14 (19%), 3 and 23F (10% each). When only the resistant serotypes were analyzed, the most prevalent was the 14 with 44%. The risk factors found in relation to the S. pneumoniae resistance were: age under one year old (p=0.01) and previous use of antibiotic (p=0.046). The resistance rates found, which were moderate to penicillin, low to cephalosporin and neutral to vancomycin, suggest the isolated use of a 3rd generation cephalosporin as an initial empirical therapy for the treatment of acute bacterial meningitis with a communitarian background.

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