Association of lamotrigine and valproate in refractory epilepsies of children and adolescents

Arquivos de Neuro-Psiquiatria

Karen P. Grisotto¹  Isac Bruck¹  Sérgio A. Antoniuk¹  Lúcia H.c. Santos¹ 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Department of PediatricsCuritiba PR ,Brazil

关键词: epilepsy;    refractory;    valproate;    lamotrigine;    childhood;    epilepsia;    refrataria;    valproato;    lamotrigina;    criança;   

DOI  :  10.1590/S0004-282X2008000400007

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the efficacy or eventual side-effects of the association of lamotrigine and sodium valproate in the control of refractory epilepsies. METHOD: A retrospective analysis of 37 children with a mean age of 12 years taking exclusivelly lamotrigine and sodium valproate. Efficacy of seizure control was considered satisfactory if there was a reduction in seizures >50% or total control. RESULTS: The association of lamotrigine and sodium valproate was considered satisfactory in 65% of the studied children, independent of seizure type. Total seizure control was obtained in 33% and 35% had an unsatisfactory response or remained unchanged. Primary generalized tonic clonic seizures were the most common type with 84% of day-time seizures having a good response to treatment. Side-effects were seen in 11% of patients and the most common was tremor. CONCLUSION: Total or satisfactory control of seizures was seen in the majority of patients and side-effects were uncommon.

【 授权许可】

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