Allergic skin rash with lamotrigine and concomitant valproate therapy: evidence for an increased risk

Arquivos de Neuro-Psiquiatria

L. M. Li¹  M. Russo¹  M. F. O'donoghue¹  J. S. Duncan¹  J. W. A. S. Sander¹ 

[1] ,The National Hospital for Neurology and Neurosurgery Institute of Neurology Epilepsy Research Group

关键词: allergic skin rash;    antiepileptic drugs;    lamotrigine;    valproate;    rash cutâneo;    drogas antiepilépticas;    lamotrigina;    valproato;   

DOI  :  10.1590/S0004-282X1996000100008

来源: SciELO

【 摘 要 】

Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02).

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