Neurobiology of apathy in Alzheimer's disease

Arquivos de Neuro-Psiquiatria

Henrique Cerqueira Guimarães²  Richard Levy¹  Antônio Lúcio Teixeira²  Rogério Gomes Beato²  Paulo Caramelli² 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Clínica MédicaBelo Horizonte,Brasil

关键词: apathy;    Alzheimer's disease;    decision-making;    orbito-frontal cortex;    anterior cingulate cortex;    basal ganglia;    dopamine;    apatia;    doença de Alzheimer;    tomada de decisão;    córtex órbito-frontal;    córtex cingulado anterior;    núcleos da base;    dopamina;   

DOI  :  10.1590/S0004-282X2008000300035

来源: SciELO

【 摘 要 】

Apathy is considered the most frequent neuropsychiatric disturbance in dementia and its outcome is generally deleterious. Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. Accordingly, in this review article, we propose a pathophysiological model to explain apathetic behavior in Alzheimer's disease, combining data from neuroimaging, neuropathology and experimental research on the role of orbito-frontal cortex, anterior cingulate cortex, basal ganglia and dopamine in decision-making neurobiology.

【 授权许可】

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