Arquivos de Neuro-Psiquiatria | |
Neurobiology of apathy in Alzheimer's disease | |
Henrique Cerqueira Guimarães2  Richard Levy1  Antônio Lúcio Teixeira2  Rogério Gomes Beato2  Paulo Caramelli2  | |
[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Departamento de Clínica MédicaBelo Horizonte,Brasil | |
关键词: apathy; Alzheimer's disease; decision-making; orbito-frontal cortex; anterior cingulate cortex; basal ganglia; dopamine; apatia; doença de Alzheimer; tomada de decisão; córtex órbito-frontal; córtex cingulado anterior; núcleos da base; dopamina; | |
DOI : 10.1590/S0004-282X2008000300035 | |
来源: SciELO | |
【 摘 要 】
Apathy is considered the most frequent neuropsychiatric disturbance in dementia and its outcome is generally deleterious. Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. Accordingly, in this review article, we propose a pathophysiological model to explain apathetic behavior in Alzheimer's disease, combining data from neuroimaging, neuropathology and experimental research on the role of orbito-frontal cortex, anterior cingulate cortex, basal ganglia and dopamine in decision-making neurobiology.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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RO202005130010257ZK.pdf | 404KB | download |