Selective hypothermia: an experimental study on traumatic brain injury in rats

Arquivos de Neuro-Psiquiatria

Amylcar Edemilson Dvilevicius¹  Mirto Nelso Prandini¹ 

[1],Universidade Federal de São Paulo EPM ,Brazil

关键词: selective hypothermia;    hypothermia;    neuroprotection;    traumatic brain injury;    hipotermia seletiva;    hipotermia;    neuroproteção;    traumatismo crânio-encefálico;   

DOI  :  10.1590/S0004-282X2008000300021

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.

【 授权许可】

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