Carcinomatous encephalitis as clinical presentation of occult lung adenocarcinoma: case report

Arquivos de Neuro-Psiquiatria

Henrique Barbosa Ribeiro²  Tadeu Ferreira De Paiva Jr²  Gustavo Pignatari Rosas Mamprin¹  Milton Luiz Gorzoni²  Antônio José Da Rocha¹  Carmen Lucia Penteado Lancellotti¹ 

[1] ,Santa Casa de São Paulo Faculty of Medical Sciences Department of Medicine

关键词: brain metastases;    carcinomatous encephalitis;    lung adenocarcinoma;    miliary brain metastases;    metástase cerebral;    encefalite carcinomatosa;    tumor primário de pulmão;    mecanismo de metástase;    metástase miliar;   

DOI  :  10.1590/S0004-282X2007000500022

来源: SciELO

【 摘 要 】

Carcinomatous encephalitis is a rare entity, originally described by Madow and Alpers in 1951, which is characterized by tumoral spreading perivascular, without mass effect. Clinical manifestations such as hemiparesis, seizures, ataxia, speech difficulties, cerebrospinal fluid findings as well as computed tomography are nonspecific. This leads the physician to pursue more frequent diseases that could explain those manifestations - toxic, metabolic, and/or infectious encephalopathy. A magnetic resonance imaging (MRI) with gadolinium, the method of choice, presumes the diagnosis. Previous reports of this unusual form of metastatic disease have described patients with prior diagnosis of pulmonary adenocarcinoma. We present the case of carcinomatous encephalitis in a 76-years-old woman as the primary manifestation of occult pulmonary adenocarcinoma with its clinical, imaging, and anatomopathological findings.

【 授权许可】

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