Rationale for the Use of Upfront Whole Brain Irradiation in Patients with Brain Metastases from Breast Cancer

International Journal of Molecular Sciences

Agnes V. Tallet⁴  David Azria⁸  Emilie Le Rhun⁹  Fabrice Barlesi⁵  Antoine F. Carpentier³  Antony Gon๺lves¹  Sophie Taillibert⁶  Frຝéric Dhermain²  Jean-Philippe Spano⁷ 

[1] Department of Medical Oncology, Institut Paoli Calmettes, Marseille 13009, France; E-Mail:;Department of Radiation Oncology, Institut Gustave Roussy University Hospital, Villejuif 94805, France; E-Mail:;Department of Neurology, Hopital Avicenne, Assistance Publique des Hopitaux de Paris, Bobigny 93000, France; E-Mail:;Department of Radiation Oncology, Institut Paoli Calmettes, Marseille 13009, France;Multidisciplinary Oncology and Therapeutic Innovations Department & Centre Investigation Clinique, Aix Marseille University—Assistance Publique Hôpitaux de Marseille, Marseille 13011, France; E-Mail:;Department of Radiation Oncology and Department of Neuro-Oncology, Pitié-Salpétrière Hospital, Paris 75013, France; E-Mail:;Department of Medical Oncology, GH Pitié-Salpêtrière, Université Paris 6, Paris 75013, France; E-Mail:;Department of Radiation Oncology and INSERM U896, CRLC Val d’Aurelle, Montpellier 34000, France; E-Mail:;Breast Unit, Department of Medical Oncology, Oscar Lambret Center, Lille Cedex 59020, France; E-Mail:

关键词: whole brain radiation therapy;    breast cancer;    brain metastases;    controlled extra-cranial disease;    overall survival;   

DOI  :  10.3390/ijms15058138

来源: mdpi

【 摘 要 】

Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland