Influence of bromazepam on cortical interhemispheric coherence

Arquivos de Neuro-Psiquiatria

Isabel Sampaio²  Fernanda Puga²  Heloisa Veiga²  Maurício Cagy¹  Roberto Piedade²  Pedro Ribeiro² 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Psiquiatria Laboratório de Mapeamento Cerebral e Integração Sensório-MotoraRio de Janeiro RJ ,Brasil

关键词: bromazepam;    qEEG;    bromazepam;    EEGq;   

DOI  :  10.1590/S0004-282X2007000100017

来源: SciELO

【 摘 要 】

Benzodiazepines are among the most commonly prescribed medications due to their therapeutic efficacy in reducing anxiety and inducing sleep. Consequently, they have been widely employed in the pharmacological treatment of several disorders. Nevertheless, few studies have analyzed the effects of bromazepam in electroencephalographic activity (EEG). The present study aimed at investigating the modulatory effects of this drug on brain dynamics. Specifically, the effects of bromazepam (3mg) on EEG coherence were tested in a double-blind experiment. The sample, consisting of 10 healthy subjects (5 male and 5 female), was submitted to ten minutes of EEG recording. The electrophysiological measure (coherence) was analyzed across three experimental conditions: bromazepam, placebo 1, and placebo 2. Results indicate that bromazepam significantly increases cortical interhemispheric coherence.

【 授权许可】

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