A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation

Arquivos de Neuro-Psiquiatria

Otoni Cardoso Do Vale²  Daniel Sá Roriz Fonteles¹  Francisco Romero Cabral¹  Manassés Claudino Fonteles¹ 

[1] ,Universidade Federal do Ceará Faculdade de Medicina Departamento de Medicina Clínica

关键词: alpha-lipoic acid;    anti-oxidant;    pro-oxidant;    cerebral ischemia;    electroencephalogram (EEG);    spectral mean absolute amplitude;    ácido alfa-lipóico;    anti-oxidante;    pró-oxidante;    isquemia cerebral;    eletrencefalograma (EEG);    amplitude absoluta média espectral;   

DOI  :  10.1590/S0004-282X2003000500007

来源: SciELO

【 摘 要 】

Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p<0.05). The left intracarotideal infusion of 6.06 mM alpha-lipoic acid significantly reverted the induced depression of mean absolute amplitude of theta and delta spectra. Nevertheless there was an increasing pattern of ischemia demonstrated by mean absolute amplitude depression of almost all EEG spectra with 60.6 mM alpha-lipoic acid infusion. These observations suggest that, depending on the administered concentration, alpha-lipoic acid may act in a dual way, protecting from ischemia at lower concentrations and worsening this process at higher doses.

【 授权许可】

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