Non increased neuron-specific enolase concentration in cerebrospinal fluid during first febrile seizures and a year follow-up in pediatric patients

Arquivos de Neuro-Psiquiatria

Alberto J. Dorta-contreras²  Edith TabÍo-valdÉs²  Alina TabÍo-valdÉs²  Caridad Delgado-fernÁndez²  Hansotto Reiber¹ 

[1] ,Hospital Pediátrico San Miguel Laboratorio Inmunología Habana,Cuba

关键词: febrile seizures;    neuron-specific enolase;    cerebrospinal fluid;    ataques febriles;    enolasa específica de neurona;    líquido cefalorraquídeo;   

DOI  :  10.1590/S0004-282X1998000400004

来源: SciELO

【 摘 要 】

Febrile seizures are the commonest acute neurological disorder of early childhood. Studies suggested that febrile seizures are previous acute events from a more serious neurological problem. Due to neuron-specific enolase is generally accepted as a marker for neuropathological processes in the brain, 16 pediatric patients were studied during their first seizures and a year after it. Neuron-specific enolase in cerebrospinal fluid and blood were analysed by an immune enzyme assay. Non pathological neuron-specific enolase values were obtained in both periods in the group of patients. There were no significative differences when paired series statistics test was performed with 95% of confidence. Neuron-specific enolase appears not to be a marker for febrile seizures because its concentration not be increased in cerebrospinal fluid in this group of patients.

【 授权许可】

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