Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease

Sleep

Olsson, Martin^1,2,3,4¹  Hedner, Jan^3,4²  Zetterberg, Henrik^1,2,5,6³  Ärlig, Johan^1,2,3⁴  Blennow, Kaj^1,2⁵ 

[1] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden^1;Department of Internal medicine, Center for Sleep and Vigilance Disorders, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden^3;Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK^5;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden^2;Sleep Laboratory, Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden^4;UK Dementia Research Institute, London, UK^6

关键词: Alzheimer’s disease;    amyloid β;    neuron-specific enolase;    orexin;    monoamine;    S100 calcium-binding protein B;    sleep deprivation;    sleep loss;    sleep;    cerebrospinal fluid;   

DOI  :  10.1093/sleep/zsy025

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesTo investigate the cumulative effect of five consecutive nights of partial sleep deprivation (PSD) on a panel of cerebrospinal fluid (CSF) biomarkers in healthy adults.

【 授权许可】

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