Alterations of cell-mediated immune response in children with febrile seizures

Arquivos de Neuro-Psiquiatria

Terezinha C.b. Montelli²  Angela M.v.c. Soares¹  Maria R. Parise-fortes¹  Maria T. Rezkallah-iwasso¹  Niura M.r. Padula²  Maria Terezinha S. Peraçoli¹ 

[1] ,School of Medicine Department of Neurology and Psychiatry

关键词: febrile seizures;    infections;    T cell subsets;    lymphocyte proliferative response;    convulsão febril;    infecções;    subpopulações de linfócitos T;    resposta proliferativa de linfócitos;   

DOI  :  10.1590/S0004-282X1997000200005

来源: SciELO

【 摘 要 】

The aim of the present investigation was to study the distribution of T-cell subsets in peripheral blood defined by monoclonal antibodies and by the lymphocyte proliferative response to phytohemagglutinin (PH A) in 30 children with febrile seizures and in 14 age-matched control subjects. Frequent respiratory, urinary and dermatologic infections were observed in 22 patients. The immunologic parameters showed that 64% of the patients presented an increased number of CD8+ cells and a low helper/suppressor ratio was observed in 60% of the patients. In addition, the proliferative response of lymphocytes to PHA was impaired in the patients. It was observed the presence of inhibitory activity on lymphocyte function in the plasma of 33% of children with febrile seizures. These results suggest that patients with febrile seizures have an impairment of cellular immunity that may be connected with this epileptic syndrome and explain the infections observed.

【 授权许可】

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