Human neurocysticercosis: IgE in cerebrospinal fluid

Arquivos de Neuro-Psiquiatria

Carmen Silvia De Melo²  Adelaide José Vaz¹  Paulo Mutuko Nakamura²  Marcos Vinicius Da Silva¹  Aluízio De Barros Barreto Machado¹ 

[1] ,Adolfo Lutz InstituteSão Paulo

关键词: neurocysticercosis;    cerebrospinal fluid;    IgE;    immunoenzymatic assay;    neurocisticercose;    líquido cefalorraquidiano;    IgE;    teste imunoenzimático;   

DOI  :  10.1590/S0004-282X1997000100002

来源: SciELO

【 摘 要 】

The detection of IgE is technically difficult because of its reduced concentrations in serum, and even lower concentrations in cerebrospinal fluid (CSF). In the present investigation we studied 86 CSF samples using an immunoenzymatic method with an anti-IgE-alkaline phosphatase conjugate and a fluorigenic substrate. The samples were from three groups: A) 29 patients with neurocysticercosis (NC), B) 36 patients with different neurologic disorders (neurosyphilis, neurotuberculosis, meningitis, tumors, hemorrhage) and C) 21 discharged individuals who had been hospitalized for bacterial meningitis. The results obtained were: A) 0.05 to 3.00 IU/ml (0.76±0.79), B) 0.00 to 1.50 IU/ml (0.23±0.34) and C) 0.05 to 1.25 IU/ml (0.34±0.34). The present results suggest that IgE appears to play a role in the pathogeny of NC and that efforts should be made to standardize a test for the detection of specific IgE antibodies.

【 授权许可】

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