Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system

Arquivos de Neuro-Psiquiatria

O. Perrella²  M. Guerriero²  E. Izzo²  M. Soscia²  P. B. Carrieri¹ 

[1] ,Hospital for Infectious DiseasesNaples

关键词: AIDS dementia complex;    cerebrospinal fluid;    cytokines (interleukin-6;    granulocyte-macrophage-CSF);    AIDS-demência complexo;    líquido cefalorraquidiano;    citocinas (interleucina-6;    granulócito-macrófago-CSF);   

DOI  :  10.1590/S0004-282X1992000200008

来源: SciELO

【 摘 要 】

We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.

【 授权许可】

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