Relationship between caga-positive Helicobacter pylori infection and risk of gastric cancer: a case control study in Porto Alegre, RS, Brazil

Arquivos de Gastroenterologia

Gilmara Coelho Meine²  Cláudia Rota¹  Judite Dietz¹  Setsuo Sekine¹  João Carlos Prolla² 

[1] ,Universidade Federal do Rio Grande do Sul

关键词: Helicobacter pylori;    Helicobacter infections;    cagA protein;    Helicobacter pylori;    Stomach neoplasms;    Helicobacter pylori;    Infecções por helicobacter;    cagA proteína;    Helicobacter pylori;    Neoplasias gástricas;   

DOI  :  10.1590/S0004-28032011000100009

来源: SciELO

【 摘 要 】

CONTEXT: Gastric cancer is the second most common cause of cancer related death worldwide. Although Helicobacter pylori has been classified as a class I carcinogen, the presence of infection is not a factor that alone is able to lead to gastric cancer, and one of the possible explanations for this is the existence of different strains of H. pylori with different degrees of virulence. OBJECTIVES: To investigate the association between cagA-positive H. pylori and gastric cancer, using polymerase chain reaction (PCR) for the detection of this bacterial strain. METHODS: Twenty-nine patients with gastric cancer were matched by sex and age (± 5 years) with 58 patients without gastric cancer, submitted to upper gastrointestinal endoscopy. All patients were evaluated for the status of infection by H. pylori (through urease test, histological analysis and PCR for the genes ureA and 16SrRNA) and by cagA-positive strain (through PCR for cagA gene). RESULTS: Evaluating the presence of infection by cagA-positive H. pylori, it was verified that the rate of infection was significantly higher in the group with gastric cancer when compared with the matched controls, occurring in 62.1% and 29.3%, respectively (OR = 3.95; CI 95% 1.543-10.096). CONCLUSIONS: There is an association between cagA-positive H. pylori strain and risk of gastric cancer.

【 授权许可】

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