Bcl-2 expression in rectal cancer

Arquivos de Gastroenterologia

Paulo C. Contu¹  Simone S. Contu¹  Luis F. Moreira¹ 

[1] ,Federal University of Rio Grande do Sul Faculty of Medicine Post-graduate Programme in SurgeryPorto Alegre RS ,Brazil

关键词: Rectal neoplasms;    Adenocarcinoma;    Proto-oncogene proteins c-bcl-2;    Immunohistochemistry;    Cell survival;    Apoptosis;    Neoplasias retais;    Adenocarcinoma;    Proteínas proto-oncogênicas c-bcl-2;    Imunoistoquímica;    Sobrevivência celular;    Apoptose;   

DOI  :  10.1590/S0004-28032006000400008

来源: SciELO

【 摘 要 】

BACKGROUD: Proteins involved in apoptosis process seem to play an important role in colorectal carcinogenesis AIM: To determine the prevalence of bcl-2 protein immunohistochemical expression and its relation with clinical and histopathological variables of rectal adenocarcinoma. PATIENTS AND METHODS: One hundred and thirty-two patients operated at "Hospital de Clínicas de Porto Alegre", Porto Alegre, RS, Brazil, between 1988 and 1999 were studied through immunohistochemical reaction using a monoclonal antibody anti-bcl-2 on formalin-fixed, paraffin-embedded tissue samples RESULTS: The prevalence of bcl-2 protein was 29.5%. There was a significant increased number of positive bcl-2 cases among women as compared to men. There was no significant association between bcl-2 and age, tumour site, histological grade, mucin production, depth of invasion, lymphatic involvement, distant metastasis or stage, despite a trend showing decreased immunoreactivity to bcl-2 among poorly and moderately differentiated tumours, as well as disseminated disease CONCLUSIONS: Analysis of bcl-2 protein expression in tumour tissues, as well as other oncoproteins, may have a role in predict therapeutic response and prognosis of colorectal cancer. However, the potential use of bcl-2 protein assessment in the clinical set for management of rectal cancer remains to be determined.

【 授权许可】

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