Inflammatory fibroid polyp: an immunohistochemical study

Arquivos de Gastroenterologia

Gilda Da Cunha Santos²  Venâncio A.f. Alves¹  Alda Wakamatsu¹  Sérgio Zucoloto¹ 

[1] ,Federal University of São Paulo School of Medicine Department of Pathology

关键词: Polyps;    Immunohistochemistry;    Gastric mucosa;    Gastrointestinal diseases;    Pólipos;    Imunoistoquímica;    Mucosa gástrica;    Gastroenteropatias;   

DOI  :  10.1590/S0004-28032004000200007

来源: SciELO

【 摘 要 】

BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.

【 授权许可】

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