Recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation

Arquivos de Gastroenterologia

Raquel F. Liermann Garcia¹  Eugenia Morales¹  Christian Evangelista Garcia¹  Sushma Saksena¹  Stefan G. HÜbscher¹  Elwin Elias¹ 

关键词: Fatty liver;    Hepatitis;    Liver transplantation;    Diabetes mellitus;    Recurrence;    Fígado gorduroso;    Hepatite;    Transplante de fígado;    Diabetes mellitus;    Recidiva;   

DOI  :  10.1590/S0004-28032001000400007

来源: SciELO

【 摘 要 】

Background — Non-alcoholic steatohepatitis was coined in 1980 to describe pathological and clinical features of non-alcoholic disease associated with pathological features, commonly seen in alcoholic-liver disease itself. It is now a well-recognised cause of end-stage liver disease and a rare cause of orthotopic liver transplantation. A small number of cases with recurrent non-alcoholic steatohepatitis following liver transplantation have been reported, however de novo non-alcoholic steatohepatitis in the liver allograft is not well recognised. Aims/Results - We report four cases of non-alcoholic steatohepatitis following orthotopic liver transplantation describing the factors related with the pathology. The recurrence of fatty infiltration occurred within 21 months and transition from mild steatosis to non-alcoholic steatohepatitis and early fibrosis was observed within 60 months post transplant in all four patients. All four cases had association with one or multiples risk factors (obesity, type 2 diabetes and/or hyperlipidemia). Conclusions - Management of this risk factors may play a therapeutic role in the prevention of recurrent and de novo non-alcoholic steatohepatitis following orthotopic liver transplantation.

【 授权许可】

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