Acute lymphoblastic leukemia presenting with bilateral serous macular detachment

Arquivos Brasileiros de Oftalmologia

Luisa Vieira¹  Nuno Aguiar Silva¹  Marco Dutra Medeiros¹  Rita Flores¹  Vitor Maduro¹ 

关键词: Acute lymphoblastic leukemia;    Serous macular detachment;    Visual acuity;    Optical coherence tomography;    Fluorescein angiography;    Leucemia linfoblástica aguda;    Descolamento seroso macular;    Acuidade visual;    Tomografia de coerência ótica;    Angiografia fluoresceínica;   

DOI  :  10.5935/0004-2749.20150101

来源: SciELO

【 摘 要 】

ABSTRACT Acute lymphoblastic leukemia is a malignant hematopoietic neoplasia, which is rare in adults. Although ocular fundus alterations may be commonly observed in the course of the disease, such alterations are rarely the presenting signs of the disease. Here we describe the case of a patient with painless and progressive loss of visual acuity (right eye, 2/10; left eye, 3/10) developing over two weeks, accompanied by fever and cervical lymphadenopathy. Fundus examination showed bilateral macular serous detachment, which was confirmed by optical coherence tomography. Fluorescein angiography revealed hyperfluorescent pinpoints in the posterior poles. The limits of the macular detachment were revealed in the late phase of the angiogram. The results of blood count analysis triggered a thorough, systematic patient examination. The diagnosis of acute lymphoblastic leukemia B (CD10+) was established, and intensive systemic chemotherapy was immediately initiated. One year after the diagnosis, the patient remains in complete remission without any ophthalmologic alterations.

【 授权许可】

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