Preoperative tranilast as adjunctive therapy to primary pterygium surgery with a 1-year follow-up

Arquivos Brasileiros de Oftalmologia

Gildásio C. Almeida Junior¹  Luciano Arakawa¹  Dalísio De Santi Neto¹  Patrícia Maluf Cury¹  Acácio A. S. Lima Filho¹  Sidney J. F. Sousa¹  Milton R. Alves¹  Reinaldo Azoubel¹ 

关键词: Transforming growth factor beta 1;    Pterygium/therapy;    Recurrence;    Autografts;    Anti-allergic agents/therapeutic use;    Transplantation;    autologous;    Conjunctiva/ surgery;    Fator de crescimento transformador beta 1;    Pterígio/terapia;    Recidiva;    Autoenxertos;    Antialérgicos/uso terapêutico;    Transplante autólogo;    Túnica conjuntiva/cirurgia;   

DOI  :  10.5935/0004-2749.20150002

来源: SciELO

【 摘 要 】

Purpose: To determine the efficacy of tranilast as an adjunctive therapy in conjunctival autograft. Methods: Twenty-nine patients were randomly allocated to the Tranilast Group (n=15) or the Control Group (n=14). The Tranilast Group received a subconjunctival injection of 0.5% tranilast 30 days prior to surgery. Conjunctival autograft was performed in both groups using fibrin sealant and 0.02% subconjunctival mitomycin C at the end of the surgery. After the resection of the pterygium, immunohistochemistry was performed with 100 cells to identify epithelial cells positive for transforming growth factor-β (TGF-β). Subjective symptoms were evaluated using a 5-point scale, and the recurrence rate was assessed. Results: Both groups showed improvements in their symptoms and similar clinical results. Compared with the Control Group, the Tranilast Group failed to show a decreased recurrence rate (p=0.59). However, the number of epithelial cells expressing TGF-β was lower in the Tranilast Group (5 cells; 95% CI: 2.56-13.15; Control Group, 16 cells, 95% CI: 11.53-24.76; p=0.01). Minimal but reversible complications, including glaucoma secondary to corticosteroids and granuloma, occurred during the study. Conclusion: Tranilast was effective in decreasing the number of pterygium epithelial cells expressing TGF-β.

【 授权许可】

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