Tear film and ocular surface changes in diabetes mellitus

Arquivos Brasileiros de Oftalmologia

Mônica De Cássia Alves²  José Barreto Carvalheira¹  Carolina Maria Módulo¹  Eduardo Melani Rocha¹ 

[1] ,Pontifícia Universidade Católica de Campinas Faculdade de Ciências Médicas Campinas SP ,Brasil

关键词: Dry eye syndromes;    Diabetes mellitus;    Oxidative stress;    Physiopathology;    Models;    animal;    Tears;    Síndrome do olho seco;    Diabetes mellitus;    Estresse oxidativo;    Modelos animais;    Lágrimas;   

DOI  :  10.1590/S0004-27492008000700018

来源: SciELO

【 摘 要 】

Diabetes mellitus and its clinical association with dry eye and ocular surface are becoming a frequent and sometimes complicate problem in Ophthalmology. Epidemiological data show that an increase in the number of patients with this association is expected following the trend to rise of the disease. The present work reviews the clinical and functional aspects of this problem. The observations indicate that metabolic, neuropathic and vascular tissue damages lead to an inflammatory process and functional degeneration. The physiopathological mechanism include hyperglycemia, advanced glycated end product accumulation, oxidative stress and inflammation mediated by NF-κB signaling pathways. Potential treatments enlightened by those findings would include antioxidant, anti-inflammatory, secretagogues and/or anabolic agents that would mimic insulin effects.

【 授权许可】

CC BY   
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