Ocular histoplasmosis-like syndrome: a report from a nonendemic area

Arquivos Brasileiros de Oftalmologia

Miguel Hage Amaro¹  Cristina Muccioli²  Mariza Toledo Abreu² 

[1] ,Universidade Federal de São Paulo Department of Ophthalmology Eye InstituteSão Paulo SP ,Brazil

关键词: Histoplasmosis;    Histoplasma;    Histoplasma;    Eye infections;    fungal;    Choroiditis;    Fluorescein angiography;    Fundus oculi;    Choroidal neovascularization;    Observational studies;    Histoplasmose;    Histoplasma;    Histoplasma;    Infecções oculares fungicas;    Coroidite;    Angiofluoresceinografia;    Fundo de olho;    Neovascularização coroidal;    Estudos observacionais;   

DOI  :  10.1590/S0004-27492007000400003

来源: SciELO

【 摘 要 】

PURPOSE: To report some cases of ocular histoplasmosis-like syndrome from a nonendemica area. DESIGN: Observational case series. METHODS: This is a prospective study of 16 eyes from 8 immunocompetent patients evaluated between January 2001 to September 2005. Six patients were female and 2 male aged between 20 to 44 years, average 28 years. All patients presented clinical features that resembled ocular histoplasmosis. All patients had a negative antibody test for histoplasmosis and negative medical and laboratory evaluation of toxoplasmosis, syphilis, and tuberculosis. All patients were submitted to a complete ocular examination including fluorescein angiography. One patient was submitted to indocyanine green angiography. RESULTS: Five patients presented the classical triad of clinical features that include peripapillary scarring, histo spots, choroidal neovascularization, one patient presentd enlargement of atrophic chorioretina scar, one patient presented multiple retinal pigment epithelial detachment, one, neovascularized retinal pigment epithelial detachment. Another patient presented only histo spots. CONCLUSION: These findings of ocular histoplasmosis-like syndrome in patients with negative antibody serum test from a nonendemica area suggest that other agents could cause these similar fundus findings of ocular histoplasmosis.

【 授权许可】

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