Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

Arquivos Brasileiros de Oftalmologia

Rodrigo Pessoa Cavalcanti Lira²  Luiz Felipe Lynch De Moraes¹  Mauro De Oliveira Júnior¹  Antônio Luiz Barbosa De Melo¹  Mirelle Souza Leão Vasconcelos¹ 

[1] ,Universidade Estadual de CampinasCampinas SP ,Brasil

关键词: Nausea;    Metoclopramide;    Fluorescein angiography;    Drug hypersensitivity;    Randomized controlled trial;    Náusea;    Metoclopramida;    Angiofluoresceinografia;    Hipersensibilidade a drogas;    Ensaio clínico controlado aleatório;   

DOI  :  10.1590/S0004-27492007000100019

来源: SciELO

【 摘 要 】

PURPOSES: To determine the efficacy of bromopride in the prophylaxis of nausea during fluorescein angiography, when compared with a placebo. METHODS: The study was a double-masked random clinical trial, between December of 2004 and April of 2005. Examinations were performed with 20% intravenous fluorescein sodium in a single dose of 2.5 ml. The patients were divided into two groups: group 1, patients who received a 2 ml intravenous dose of 5 mg/ml bromopride and group 2, patients who received a 2 ml intravenous dose of 0.9% sodium chloride (placebo), both 20 minutes before the dye injection. Cases of nausea were observed during and after the examination. RESULTS: 352 patients were enrolled, 176 in each group. Cases of nausea were observed in 12 (6.8%) patients of the bromopride group and in 11 (6.3%) patients of the placebo group (p<0.829 - relative risk=1.05). CONCLUSION: Bromopride did not prevent the occurrence of nausea in fluorescein angiography, when compared with a placebo.

【 授权许可】

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