Prevalence and Fluconazole Susceptibility Profile of Candida spp. Clinical Isolates in a Brazilian Tertiary Hospital in Minas Gerais, Brazil

Anais da Academia Brasileira de Ciências

Athayde Neves-junior¹  Ana Carolina Cartágenes-pinto¹  Débora A.s. Rocha¹  Leandro F. Reis De Sá¹  Maria De Lourdes Junqueira¹  Antonio Ferreira-pereira¹ 

关键词: Candidaspp.;    clinical isolates;    epidemiology;    fluconazole;    resistance;    Candidaspp;    isolados clínicos;    epidemiologia;    fluconazol;    resistência;   

DOI  :  10.1590/0001-3765201520140717

来源: SciELO

【 摘 要 】

Candidiasis has become an important concern for clinical practice, especially with the increasing incidence of immunocompromised patients. In this scenario, the development resistance to fluconazole presents a challenge for treating these opportunistic infections. The aim of this study was to evaluate some epidemiology features of Candidainfections in a Brazilian University Hospital using data, previously unavailable. We observed that 44% of the 93 clinical isolates tested, belonged to Candida albicansspecies and 56% belonged to non-Candida albicansspecies (mainly Candida tropicalis and Candida glabrata). Most strains were isolated from urine samples where C. albicans was predominantly detected. 29 strains presented a fluconazole resistance phenotype and of these, 22 were chemosensitised by FK506, a classical inhibitor of ABC transporters related to azoles resistance. These data suggest the probable role of efflux pumps in this resistance phenotype. Our study highlights the need for developing effective control measures for fungal infections, rational use of antifungal drugs and development of new molecules able to abrogate the active transport of antifungals.

【 授权许可】

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